Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia.

Post-mortem brains were donated by the Stanley Foundation Brain Bank Consortium courtesy of Llewellyn B Bigelow, Maree J Webster and staff. We thank the donors,Daire Quinn, Sinead Kinsella, Alison Gordon and Magdalena Hryniewiecka, for help with western blotting and animal work; Andrew Pocklington and George Kirov for the PSD gene lists, and Aniket Misra, Stuart MacGregor and Dave Hill for help with the gene-based analysis. We thank the Psychiatric Genetics Consortium, DIAGRAM(DIAbetes Genetics Replication And Meta-analysis) Consortium and International Inflammatory Bowel Disease Genetics Consortium (IIBDGC) for providing genome-wide association study data. Access to and use of mass spectrometry instrumentation and computing facilities at the Conway Institute is gratefully acknowledged. This work was supported by a Brain and Behavior Research Foundation Award (to MF), the SMRI and the Irish Health Research Board through a Health Research Award (to DC,GC and MF) and a Health Research Board Clinician Scientist Award (to DC).