RGD conjugated switch on NIR-fluorophores for fluorescence guided cancer surgeries.pdf (488.01 kB)
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RGD conjugated switch on near infrared-fluorophores for fluorescence guided cancer surgeries

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journal contribution
posted on 18.11.2021, 16:53 by Yuan GeYuan Ge, Donal O'SheaDonal O'Shea

The development by Paul Ehrlich and others of colorimetric tissue staining with synthetic dyes is recognised as marking the beginning of modern medical scientific research. A century and a half later, molecular fluorescence imaging as a technique to visualise specific regions of live cellular or whole organisms is central to many biomedical research programs. Within the imaging spectral range, the near infrared (NIR) region (700-1,000 nm) provides optimal wavelengths for reduced light toxicity, avoidance of endogenous chromophore absorbance and auto-fluorescence. An exciting new potential of NIR fluorescence imaging is that the tools developed for cellular and in vivo small animal research could be translatable to human surgical medicine.

History

Comments

The original article is available at https://www.futuremedicine.com

Published Citation

Ge Y, O'Shea DF. RGD conjugated switch on near infrared-fluorophores for fluorescence guided cancer surgeries. Future Oncol. 2019;15(36):4123-4125.

Publication Date

3 December 2019

PubMed ID

31794258

Department/Unit

  • Chemistry

Research Area

  • Cancer
  • Surgical Science and Practice
  • Chemistry and Pharmaceutical Sciences

Publisher

Future Medicine Ltd

Version

  • Published Version (Version of Record)