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Randomized controlled trial of convalescent plasma therapy against standard therapy in patients with severe COVID-19 disease

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posted on 11.01.2022, 17:05 authored by Manaf AlQahtani, Abdulkarim Abdulrahman, Abdulrahman Almadani, Salman Yousif Alali, Alaa Mahmood Al Zamrooni, Amal Hamza Hejab, Ronan ConroyRonan Conroy, Pearl Wasif, Sameer Otoom, Stephen L Atkin, Manal Abduljalil
Convalescent plasma (CP) therapy in COVID-19 disease may improve clinical outcome in severe disease. This pilot study was undertaken to inform feasibility and safety of further definitive studies. This was a prospective, interventional and randomized open label pilot trial in patients with severe COVID-19. Twenty COVID-19 patients received two 200 ml transfusions of convalescent patient CP over 24-h compared with 20 who received standard of care. The primary outcome was the requirement for ventilation (non-invasive or mechanical ventilation). The secondary outcomes were biochemical parameters and mortality at 28 days. The CP group were a higher risk group with higher ferritin levels (p < 0.05) though respiratory indices did not differ. The primary outcome measure was required in 6 controls and 4 patients on CP (risk ratio 0.67, 95% CI 0.22–2.0, p = 0.72); mean time on ventilation (NIV or MV) did not differ. There were no differences in secondary measures at the end of the study. Two patients died in the control and one patient in the CP arm. There were no significant differences in the primary or secondary outcome measures between CP and standard therapy, although a larger definitive study is needed for confirmation. However, the study did show that CP therapy appears to be safe in hospitalized COVID-19 patients with hypoxia. Clinical trials registration NCT04356534: 22/04/2020.

Funding

Ministry of Health Bahrain

Royal of Surgeons in Ireland - Bahrain

History

Comments

The original article is available at https://www.nature.com/

Published Citation

AlQahtani M. et al. Randomized controlled trial of convalescent plasma therapy against standard therapy in patients with severe COVID-19 disease. Sci Rep. 2021;11(1):9927

Publication Date

11 May 2021

PubMed ID

33976287

Department/Unit

  • Data Science Centre
  • RCSI Bahrain

Research Area

  • Health Professions Education
  • Cancer
  • Neurological and Psychiatric Disorders
  • Population Health and Health Services

Publisher

Springer Science and Business Media LLC

Version

  • Published Version (Version of Record)