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Repositioning natural antioxidants for therapeutic applications in tissue engineering.

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journal contribution
posted on 05.08.2021, 11:32 authored by Pasquale Marrazzo, Cian O'LearyCian O'Leary
Although a large panel of natural antioxidants demonstrate a protective effect in preventing cellular oxidative stress, their low bioavailability limits therapeutic activity at the targeted injury site. The importance to deliver drug or cells into oxidative microenvironments can be realized with the development of biocompatible redox-modulating materials. The incorporation of antioxidant compounds within implanted biomaterials should be able to retain the antioxidant activity, while also allowing graft survival and tissue recovery. This review summarizes the recent literature reporting the combined role of natural antioxidants with biomaterials. Our review highlights how such functionalization is a promising strategy in tissue engineering to improve the engraftment and promote tissue healing or regeneration.



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Published Citation

Marrazzo P, O'Leary C. Repositioning natural antioxidants for therapeutic applications in tissue engineering. Bioengineering (Basel). 2020;7(3):104.

Publication Date

2 September 2020

PubMed ID



  • Amber (Advanced Material & Bioengineering Research) Centre
  • School of Pharmacy and Biomolecular Sciences

Research Area

  • Respiratory Medicine
  • Chemistry and Pharmaceutical Sciences
  • Cancer
  • Biomaterials and Regenerative Medicine




  • Published Version (Version of Record)