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Safety and efficacy of low-dose corticosteroids in patients with non-severe coronavirus disease 2019: a retrospective cohort study

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posted on 04.02.2022, 16:32 authored by Talal Almas, Maryam Ehtesham, Abdul Wali Khan, Tarek Khedro, Salman Hussain, Mehwish Kaneez, Reema Alsufyani, Dana Almubarak, Fatimah Alahmed, Hasan Alaeddin
Background: To date, several pharmacological agents have been employed in the treatment and management of the coronavirus disease 2019 (COVID-19). While the utility of corticosteroids in severe COVID-19 infection is now widely touted, their efficacy in thwarting the progression of non-severe disease remains elusive.
Methods: A retrospective cohort study involving 25 patients with a confirmed diagnosis of non-severe COVID-19 infection was conducted. Subjects were assigned to either the steroid or the non-steroid group. A low-dose, short-course corticosteroid regimen was administered for seven days and the disease outcomes were recorded and compared among the two groups. The Kolmogorov-Smirnov test was employed to discern the data normality.
Results: In patients treated with low-dose, short-course steroids, the overall all-cause mortality was significantly lower compared with the non-steroid group (8.3% and 61.5%, respectively; p = 0.005). The prevalence of acute respiratory distress syndrome in the steroid group was significantly lower than that in the non-steroid group at the seven-day mark (16.7% and 84.6%, respectively; p = 0.002). Within the steroid group, the incidence of developing secondary complications was also markedly lower than that in the non-steroid group.
Conclusions: In patients afflicted with non-severe COVID-19, the employment of low-dose, short-course corticosteroids may confer a therapeutic advantage, significantly curtailing the mortality rate, the length of hospital stay, and the risk of developing secondary complications.

History

Comments

The original article is available at https://www.cureus.com/

Published Citation

Almas T,. et al. Safety and efficacy of low-dose corticosteroids in patients with non-severe coronavirus disease 2019: a retrospective cohort study. Cureus. 2021;13(1):e12544.

Publication Date

7 January 2021

PubMed ID

33564538

Department/Unit

  • Undergraduate Research

Publisher

Cureus, Inc

Version

  • Published Version (Version of Record)