Scaffold-based Delivery of Nucleic Acid Therapeutics for Enhanced Bone and Cartilage Repair.
Recent advances in tissue engineering have made progress towards the development of biomaterials capable of the delivery of growth factors, such as BMPs, in order to promote enhanced tissue repair. However, controlling the release of these growth factors on demand and within the desired localised area is a significant challenge and the associated high costs and side effects of uncontrolled delivery have proven increasingly problematic in clinical orthopaedics. Gene therapy may be a valuable tool to avoid the limitations of local delivery of growth factors. Following a series of setbacks in the 1990's, the field of gene therapy is now seeing improvements in safety and efficacy resulting in substantial clinical progress and a resurgence in confidence. Biomaterial scaffold-mediated gene therapy provides a template for cell infiltration and tissue formation while promoting transfection of cells to engineer therapeutic proteins in a sustained but ultimately transient fashion. Additionally, scaffold-mediated delivery of RNA-based therapeutics can silence specific genes associated with orthopaedic pathological states. This review will provide an overview of the current state-of-the-art in the field of gene-activated scaffolds and their use within orthopaedic tissue engineering applications. This article is protected by copyright. All rights reserved.
Science Foundation Ireland (SFI) under the European Regional Development Fund under Curam,Grant Number 13/RC/2073, and by the Irish Research Council Government of Ireland Postgraduate Programme (GOIPG/2018/371).
Comments"This is the peer reviewed version of the following article:, Kelly DC, Raftery RM, Curtin CM, O'Driscoll CM, O'Brien FJ. Scaffold-based Delivery of Nucleic Acid Therapeutics for Enhanced Bone and Cartilage Repair. Journal of Orthopaedic Research. 2019;, which has been published in final form at DOI: 10.1002/jor.24321. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
Published CitationKelly DC, Raftery RM, Curtin CM, O'Driscoll CM, O'Brien FJ. Scaffold-based Delivery of Nucleic Acid Therapeutics for Enhanced Bone and Cartilage Repair. Journal of Orthopaedic Research. 2019;
- Amber (Advanced Material & Bioengineering Research) Centre
- Anatomy and Regenerative Medicine
- Tissue Engineering Research Group (TERG)