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Seasonal and daytime variation in multiple immune parameters in humans: evidence from 329,261 participants of the UK Biobank cohort

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posted on 25.04.2022, 16:05 authored by Cathy Wyse, Grace O'MalleyGrace O'Malley, Andrew N Coogan, Samuel McConkeySamuel McConkey, Daniel J Smith

Seasonal disease outbreaks are perennial features of human infectious disease but the factors generating these patterns are unclear. Here we investigate seasonal and daytime variability in multiple immune parameters in 329,261 participants in UK Biobank and test for associations with a wide range of environmental and lifestyle factors, including changes in day length, outdoor temperature and vitamin D at the time the blood sample was collected. Seasonal patterns were evident in lymphocyte and neutrophil counts, and C-reactive protein CRP, but not monocytes, and these were independent of lifestyle, demographic, and environmental factors. All the immune parameters assessed demonstrated significant daytime variation that was independent of confounding factors. At a population level, human immune parameters vary across season and across time of day, independent of multiple confounding factors. Both season and time of day are fundamental dimensions of immune function that should be considered in all studies of immuno-prophylaxis and disease transmission.

Funding

MRC Mental Health Data Pathfinder Award (MC_PC_17217)

Lister Institute Prize Fellowship (2016-2021)

RCSI Strategic Academic Recruitment (StAR) Fellowship

History

Comments

The original article is available at https://www.cell.com/

Published Citation

Wyse C, O'Malley G, Coogan AN, McConkey S, Smith DJ. Seasonal and daytime variation in multiple immune parameters in humans: Evidence from 329,261 participants of the UK Biobank cohort. iScience. 2021;24(4):102255

Publication Date

1 March 2021

PubMed ID

33817568

Department/Unit

  • International Health and Tropical Medicine
  • School of Physiotherapy

Research Area

  • Health Professions Education
  • Immunity, Infection and Inflammation
  • Population Health and Health Services
  • Endocrinology

Publisher

Elsevier BV

Version

  • Published Version (Version of Record)