Royal College of Surgeons in Ireland
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Sepsis – it is all about the platelets

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journal contribution
posted on 2023-11-17, 10:26 authored by Dermot CoxDermot Cox
Sepsis is accompanied by thrombocytopenia and the severity of the thrombocytopenia is associated with mortality. This thrombocytopenia is characteristic of disseminated intravascular coagulation (DIC), the sepsis-associated coagulopathy. Many of the pathogens, both bacterial and viral, that cause sepsis also directly activate platelets, which suggests that pathogen-induced platelet activation leads to systemic thrombosis and drives the multi-organ failure of DIC. In this paper we review the mechanisms of platelet activation by pathogens and the evidence for a role for anti-platelet agents in the management of sepsis.



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Published Citation

Cox D. Sepsis - it is all about the platelets. Front Immunol. 2023;14:1210219

Publication Date

7 June 2023

PubMed ID



  • School of Pharmacy and Biomolecular Sciences

Research Area

  • Immunity, Infection and Inflammation
  • Vascular Biology


Frontiers Research Foundation


  • Published Version (Version of Record)