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Shining a light on metabolic vulnerabilities in non-small cell lung cancer.
journal contributionposted on 15.12.2020, 18:12 by Catriona Dowling, Hua Zhang, Triona Ni ChonghaileTriona Ni Chonghaile, Kwok-Kin Wong
Metabolic reprogramming is a hallmark of cancer which contributes to essential
processes required for cell survival, growth, and proliferation. Non-small cell lung cancer
(NSCLC) is the most common type of lung cancer and its genomic classification has given rise
to the design of therapies targeting tumors harboring specific gene alterations that cause
aberrant signaling. Lung tumors are characterized with having high glucose and lactate use,
and high heterogeneity in their metabolic pathways. Here we review how NSCLC cells with
distinct mutations reprogram their metabolic pathways and highlight the potential metabolic
vulnerabilities that might lead to the development of novel therapeutic strategies.
H2020 MSCA Global Fellowship (799724)
NIH grant CA233084-01
NIH grant CA219670
NIH grant CA216188
CommentsThe original article is available at https://www.sciencedirect.com
Published CitationDowling CM, Zhang H, Ni Chonghaile T, Wong KK. Shining a light on metabolic vulnerabilities in non-small cell lung cancer. Biochimica et Biophysica Acta - Reviews on Cancer. 2021;1875(1):188462.
Publication Date29 October 2020
- Physiology and Medical Physics
- Accepted Version (Postprint)