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Short-term air pollution as a risk for stroke admission: a time-series analysis

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posted on 23.11.2021, 17:12 by Colm ByrneColm Byrne, Kathleen BennettKathleen Bennett, Anne HickeyAnne Hickey, Paul KavanaghPaul Kavanagh, Brian Broderick, Margaret O'Mahony, David WilliamsDavid Williams

Background: The harmful effects of outdoor air pollution on stroke incidence are becoming increasingly recognised. We examined the impact of different air pollutants (PM2.5, PM10, NO2, ozone, and SO2) on admission for all strokes in two Irish urban centres from 2013 to 2017.

Methods: Using an ecological time series design with Poisson regression models, we analysed daily hospitalisation for all strokes and is-chaemic stroke by residence in Dublin or Cork, with air pollution level monitoring data with a lag of 0-2 days from exposure. Splines of temperature, relative humidity, day of the week, and time were included as confounders. Analysis was also performed across all four seasons. Data are presented as relative risks (RRs) and 95% confidence intervals (95% CI) per interquartile range (IQR) increase in each pollutant.

Results: There was no significant association between all stroke admission and any individual air pollutant. On seasonal analysis, during winter in the larger urban centre (Dublin), we found an association between all stroke cases and an IQR increase in NO2 (RR 1.035, 95% CI: 1.003-1.069), PM10 (RR 1.032, 95% CI: 1.007-1.057), PM2.5 (RR 1.024, 95% CI: 1.011-1.039), and SO2 (RR 1.035, 95% CI: 1.001-1.071). There was no significant association found in the smaller urban area of Cork. On meta-analysis, there remained a significant association between NO2 (RR 1.013, 95% CI: 1.001-1.024) and PM2.5 (1.009, 95% CI 1.004-1.014) per IQR increase in each.

Discussion: Short-term air pollution in winter was found to be associated with hospitalisation for all strokes in a large urban centre in Ireland. As Ireland has relatively low air pollution internationally, this highlights the need to introduce policy changes to reduce air pollution in all countries.

History

Comments

This is the accepted manuscript version of an article published by S. Karger AG in Byrne CP, Bennett KE, Hickey A, Kavanagh P, Broderick B, O'Mahony M, Williams DJ. Short-term air pollution as a risk for stroke admission: a time-series analysis. Cerebrovasc Dis. 2020;49(4):404-411. DOI: https://doi.org/10.1159/000510080

Published Citation

Byrne CP. et al. Short-term air pollution as a risk for stroke admission: a time-series analysis. Cerebrovasc Dis. 2020;49(4):404-411.

Publication Date

10 August 2020

PubMed ID

32777785

Department/Unit

  • Beaumont Hospital
  • Data Science Centre
  • Health Psychology
  • Medicine
  • Public Health and Epidemiology

Research Area

  • Neurological and Psychiatric Disorders
  • Population Health and Health Services
  • Vascular Biology

Publisher

S. Karger AG

Version

  • Accepted Version (Postprint)