Terminal sialylation determines plasma VWF half-life. A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed. In this study, we show that MGL influences physiological plasma VWF clearance. MGL inhibition was associated with a significantly extended mean residence time and 3-fold increase in endogenous plasma VWF:Ag levels (p.
Funding
NIH for the Zimmerman Program (HL081588)
Science Foundation Ireland Principal Investigator Award (11/PI/1066)
Health Research Board Investigator Lead Project Award (ILP-POR-2017-008)
National Children’s Research Centre Project Award (C/18/1)
European Union (GlySign, Grant No. 722095)
History
Comments
The original article is available at https://haematologica.org
Published Citation
Ward SE. et al. Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance. Haematologica. 2022;107(3):668-679