Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin mediated clearance.
journal contributionposted on 21.06.2021, 14:22 by Soracha Enright WardSoracha Enright Ward, Jamie O'SullivanJamie O'Sullivan, Alan B Moran, Daniel IR Spencer, Richard A Gardner, Jyotika Sharma, Judicael FrazavanaJudicael Frazavana, Marco MonopoliMarco Monopoli, Thomas AJ McKinnon, Alain Chion, Sandra Haberichter, James O'DonnellJames O'Donnell
Terminal sialylation determines plasma VWF half-life. A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed. In this study, we show that MGL influences physiological plasma VWF clearance. MGL inhibition was associated with a significantly extended mean residence time and 3-fold increase in endogenous plasma VWF:Ag levels (p.
NIH for the Zimmerman Program (HL081588)
Science Foundation Ireland Principal Investigator Award (11/PI/1066)
Health Research Board Investigator Lead Project Award (ILP-POR-2017-008)
National Children’s Research Centre Project Award (C/18/1)
European Union (GlySign, Grant No. 722095)
CommentsThe original article is available at https://haematologica.org
Published CitationWard SE, O'Sullivan JM, Moran AB, Spencer DIR, Gardner RA, Sharma J, Fazavana J, Monopoli M, McKinnon TAJ, Chion A, Haberichter S, O'Donnell JS. Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin mediated clearance. Haematologica. 2021.
Publication Date25 March 2021
- Irish Centre for Vascular Biology
- School of Pharmacy and Biomolecular Sciences
- Vascular Biology
- Health Professions Education
- Immunity, Infection and Inflammation
PublisherFerrata Storti Foundation (Haematologica)
- Accepted Version (Postprint)