Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin mediated clearance..pdf (6.85 MB)

Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin mediated clearance.

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journal contribution
posted on 21.06.2021, 14:22 by Soracha Enright Ward, Jamie O'Sullivan, Alan B Moran, Daniel IR Spencer, Richard A Gardner, Jyotika Sharma, Judicael Frazavana, Marco Monopoli, Thomas AJ McKinnon, Alain Chion, Sandra Haberichter, James O'Donnell
Terminal sialylation determines plasma VWF half-life. A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed. In this study, we show that MGL influences physiological plasma VWF clearance. MGL inhibition was associated with a significantly extended mean residence time and 3-fold increase in endogenous plasma VWF:Ag levels (p.

Funding

NIH for the Zimmerman Program (HL081588)

Science Foundation Ireland Principal Investigator Award (11/PI/1066)

Health Research Board Investigator Lead Project Award (ILP-POR-2017-008)

National Children’s Research Centre Project Award (C/18/1)

European Union (GlySign, Grant No. 722095)

History

Comments

The original article is available at https://haematologica.org

Published Citation

Ward SE, O'Sullivan JM, Moran AB, Spencer DIR, Gardner RA, Sharma J, Fazavana J, Monopoli M, McKinnon TAJ, Chion A, Haberichter S, O'Donnell JS. Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin mediated clearance. Haematologica. 2021.

Publication Date

25 March 2021

PubMed ID

33763999

Department/Unit

  • Chemistry
  • Irish Centre for Vascular Biology
  • School of Pharmacy and Biomolecular Sciences

Research Area

  • Vascular Biology
  • Health Professions Education
  • Cancer
  • Immunity, Infection and Inflammation

Publisher

Ferrata Storti Foundation (Haematologica)

Version

  • Accepted Version (Postprint)