Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance.pdf (4.85 MB)
Download fileSialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin mediated clearance.
journal contribution
posted on 2022-04-11, 13:27 authored by Soracha Enright Ward, Jamie O'SullivanJamie O'Sullivan, Alan B Moran, Daniel IR Spencer, Richard A Gardner, Jyotika Sharma, Judicael Frazavana, Marco MonopoliMarco Monopoli, Thomas AJ McKinnon, Alain Chion, Sandra Haberichter, James O'DonnellJames O'DonnellTerminal sialylation determines plasma VWF half-life. A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed. In this study, we show that MGL influences physiological plasma VWF clearance. MGL inhibition was associated with a significantly extended mean residence time and 3-fold increase in endogenous plasma VWF:Ag levels (p.
Funding
NIH for the Zimmerman Program (HL081588)
Science Foundation Ireland Principal Investigator Award (11/PI/1066)
Health Research Board Investigator Lead Project Award (ILP-POR-2017-008)
National Children’s Research Centre Project Award (C/18/1)
European Union (GlySign, Grant No. 722095)
History
Comments
The original article is available at https://haematologica.orgPublished Citation
Ward SE. et al. Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance. Haematologica. 2022;107(3):668-679Publication Date
25 March 2021External DOI
PubMed ID
33763999Department/Unit
- Chemistry
- Irish Centre for Vascular Biology
- School of Pharmacy and Biomolecular Sciences
Research Area
- Vascular Biology
- Health Professions Education
- Cancer
- Immunity, Infection and Inflammation
Publisher
Ferrata Storti Foundation (Haematologica)Version
- Published Version (Version of Record)
CC BY-NC 4.0