Significant gynecological bleeding in women with low von Willebrand factor levels.
Gynecological bleeding is frequently reported in women with von Willebrand disease (VWD). Low von Willebrand factor (VWF) may be associated with significant bleeding phenotype despite only mild plasma VWF reductions. The contribution of gynecological bleeding to this phenotype has yet to be described. The optimal clinical bleeding assessment tool (BAT) to evaluate bleeding remains unclear. Using a standardized approach to phenotypic assessment, we evaluated gynecological bleeding and directly compared the Condensed Molecular and Clinical Markers for the Diagnosis and Management of type 1 VWD (Condensed MCMDM-1 VWD) and International Society on Thrombosis and Haemostasis (ISTH) BAT scores in 120 women enrolled in the Low von Willebrand in Ireland Cohort study. Heavy menstrual bleeding (HMB) was reported in 89% of female participants; 45.8% developed iron deficiency. Using identical data, Condensed MCMDM-1 VWD menorrhagia domain scores were significantly lower than ISTH BAT scores (2 vs 3;
Irish Health Research Board Health Research Award (HRA-POR-2014-529) (J.S.O.) and a Science Foundation Ireland Principal Investigator Award (11/PI/1066) (J.S.O.).
CommentsThis research was originally published in Blood Advances. Lavin M, Aguila S, Dalton N, Nolan M, Byrne M, Ryan K, White B, O’Connell NM, O’Sullivan JM, Di Paola J, James PD, O’Donnell JS. Blood Adv. 2018;2(14):1784-1791. © the American Society of Hematology.
Published CitationLavin M, Aguila S, Dalton N, Nolan M, Byrne M, Ryan K, White B, O’Connell NM, O’Sullivan JM, Di Paola J, James PD, O’Donnell JS. Blood Advances. 2018;2(14):1784-1791
- Irish Centre for Vascular Biology
- School of Pharmacy and Biomolecular Sciences