Source-based morphometry reveals structural brain pattern abnormalities in 22q11.2 deletion syndrome
22q11.2 deletion syndrome (22q11DS) is the most frequently occurring microdeletion in humans. It is associated with a significant impact on brain structure, including prominent reductions in gray matter volume (GMV), and neuropsychiatric manifestations, including cognitive impairment and psychosis. It is unclear whether GMV alterations in 22q11DS occur according to distinct structural patterns. Then, 783 participants (470 with 22q11DS: 51% females, mean age [SD] 18.2 [9.2]; and 313 typically developing [TD] controls: 46% females, mean age 18.0 [8.6]) from 13 datasets were included in the present study. We segmented structural T1-weighted brain MRI scans and extracted GMV images, which were then utilized in a novel source-based morphometry (SBM) pipeline (SS-Detect) to generate structural brain patterns (SBPs) that capture co-varying GMV. We investigated the impact of the 22q11.2 deletion, deletion size, intelligence quotient, and psychosis on the SBPs. Seventeen GMV-SBPs were derived, which provided spatial patterns of GMV covariance associated with a quantitative metric (i.e., loading score) for analysis. Patterns of topographically widespread differences in GMV covariance, including the cerebellum, discriminated individuals with 22q11DS from healthy controls. The spatial extents of the SBPs that revealed disparities between individuals with 22q11DS and controls were consistent with the findings of the univariate voxel-based morphometry analysis. Larger deletion size was associated with significantly lower GMV in frontal and occipital SBPs; however, history of psychosis did not show a strong relationship with these covariance patterns. 22q11DS is associated with distinct structural abnormalities captured by topographical GMV covariance patterns that include the cerebellum. Findings indicate that structural anomalies in 22q11DS manifest in a nonrandom manner and in distinct covarying anatomical patterns, rather than a diffuse global process. These SBP abnormalities converge with previously reported cortical surface area abnormalities, suggesting disturbances of early neurodevelopment as the most likely underlying mechanism.
Funding
Big Data to Knowledge (BD2K) Program. Grant Number: U54EB020403
Dalglish Family Chair
Canadian Institutes of Health Research (CIHR). Grant Numbers: MOP-111238, MOP-313331
NIMH. Grant Numbers: U01MH101719, R01MH085953, U01MH119741-01, U01MH119758
NIH. Grant Numbers: U54HD079125, R01MH107018, U01MH101724, U01MH119738, 5U01MH119737-04, R01 MH064824, R01MH129636, K01MH112774, R01MH129742-01, R01AG058854-02, R01MH116147-04
Innovative Medicines Initiative 2 Joint Undertaking. Grant Numbers: 777394, 115300
Wellcome Trust Clinical Research Training Fellowship. Grant Number: 102003/Z/13/Z
Tommy Fuss Center for Neuropsychiatric Research
Wellcome Trust Strategic Award “DEFINE”
MRC. Grant Numbers: MR/L011166/1, MR/N022572/1, MR/T033045/1
Fondecyt. Grant Numbers: ACT 192064, 1211411, 1171014
The SickKids Psychiatry Associates Chair in Developmental Psychopathology
European Commision grant. Grant Number: QLGU-CT-2001–01081
NWO-Veni grant. Grant Number: 2006-916.76.048
Dutch Brain Foundation. Grant Number: 15F07(2).55
History
Data Availability Statement
The data used for the analysis are made available upon request to the ENIGMA 22q11.2 Working Group.Comments
The original article is available at https://onlinelibrary.wiley.com/Published Citation
Ge R, et al. Source-based morphometry reveals structural brain pattern abnormalities in 22q11.2 deletion syndrome. Hum Brain Mapp. 2024;45(1):e26553.Publication Date
12 January 2024External DOI
PubMed ID
38224541Department/Unit
- Psychiatry
Publisher
John Wiley & Sons, IncVersion
- Published Version (Version of Record)