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Spatiotemporally resolved heat dissipation in 3D patterned magnetically responsive hydrogels

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journal contribution
posted on 22.12.2021, 10:44 by Patricia MonksPatricia Monks, Jacek K Wychowaniec, Eoin McKiernan, Shane Clerkin, John Crean, Brian J Rodriguez, Emmanuel G Reynaud, Andreas HeiseAndreas Heise, Dermot F Brougham
Multifunctional nanocomposites that exhibit well-defined physical properties and encode spatiotemporally controlled responses are emerging as components for advanced responsive systems, for example, in soft robotics or drug delivery. Here an example of such a system, based on simple magnetic hydrogels composed of iron oxide magnetic nanoflowers and Pluronic F127 that generates heat upon alternating magnetic field irradiation is described. Rules for heat-induction in bulk hydrogels and the heat-dependence on particle concentration, gel volume, and gel exposed surface area are established, and the dependence on external environmental conditions in “closed” as compared to “open” (cell culture) system, with controllable heat jumps, of ∆T 0–12°C, achieved within ≤10 min and maintained described. Furthermore the use of extrusion-based 3D printing for manipulating the spatial distribution of heat in well-defined printed features with spatial resolution <150 µm, sufficiently fine to be of relevance to tissue engineering, is presented. Finally, localized heat induction in printed magnetic hydrogels is demonstrated through spatiotemporally-controlled release of molecules (in this case the dye methylene blue). The study establishes hitherto unobserved control over combined spatial and temporal induction of heat, the applications of which in developing responsive scaffold remodeling and cargo release for applications in regenerative medicine are discussed.

Funding

Science Foundation Ireland (16/IA/4584, 13/IA/1840, and 13/TIDA/B2701)

Enterprise Ireland (CF-2016-0389-P)

History

Comments

This is the peer reviewed version of the following article:, Monks P. et al. Spatiotemporally resolved heat dissipation in 3d patterned magnetically responsive hydrogels. Small. 2021;17(5):e2004452, which has been published in final form at https://doi.org/10.1002/smll.202004452. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Published Citation

Monks P. et al. Spatiotemporally resolved heat dissipation in 3D patterned magnetically responsive hydrogels. Small. 2021;17(5):e2004452

Publication Date

28 December 2020

PubMed ID

33369876

Department/Unit

  • Chemistry

Research Area

  • Biomaterials and Regenerative Medicine
  • Chemistry and Pharmaceutical Sciences

Publisher

Wiley

Version

  • Accepted Version (Postprint)