Successful clozapine re-challenge in a patient with three previous episodes of clozapine-associated blood dyscrasia

Foster, Jessica; Lally, John; Bell, Victoria; Shergill, Sukhi

Successful clozapine re-challenge in a patient with three previou.pdf (139.39 kB)

Successful clozapine re-challenge in a patient with three previous episodes of clozapine-associated blood dyscrasia

journal contribution

posted on 2021-09-27, 14:50 authored by Jessica Foster, John LallyJohn Lally, Victoria Bell, Sukhi Shergill

A case is presented of a 30-year-old female with treatment-resistant schizoaffective disorder who was referred to a tertiary-level specialist psychosis service. We describe the history of clozapine trials and associated episodes of agranulocytosis and neutropenia, followed by the successfully tolerated third clozapine re-challenge within our service.

Funding

S.S. is supported by a European Research Council Consolidator Award (grant number 311686), and some of this work was supported by a Medical Research Council New Investigator award to S.S. (grant number G0901868) and developed by the National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The funders of the study had no role in study design, data collection, data analysis, data interpretation or writing of the report.

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This article is also available at http://bjpo.rcpsych.org/content/3/1/22.full-text.pdf+html

Published Citation

Foster J, Lally J, Bell V, Shergill S. Successful clozapine re-challenge in a patient with three previous episodes of clozapine-associated blood dyscrasia. British Journal of Psychiatry Open. 2017;3:22-25.