Survival in an era of organ preservation: an update on laryngeal cancer in Ireland
Background: Laryngeal cancer epidemiology has changed in recent years, with falling incidence observed internationally. Organ preservation therapies have revolutionised management, though some patients may be unsuitable and survival was noted to fall in the 2000s. This study examines trends in laryngeal cancer in Ireland.
Methods: A retrospective cohort study of National Cancer Registry of Ireland data from 1994 to 2014.
Results: From a cohort of 2651, glottic disease was most common (62%, n = 1646). Incidence rose to 3.43 cases/100,000/year for 2010–2014. 5-year disease-specific survival (DSS) was 60.6% and did not change significantly over time. Overall survival (OS) for T3 disease managed with primary radiotherapy was similar to primary surgery (HR 0.98, p = 0.9). DSS for T3 disease improved with primary radiotherapy (HR 0.72, p = 0.045).
Conclusion: Incidence of laryngeal cancer in Ireland rose despite international trends, while survival changed little. Radiotherapy improves DSS for T3 disease but does not improve OS, possibly secondary to poor organ function post-radiotherapy.
Funding
Open Access funding provided by the IReL Consortium
History
Data Availability Statement
Stored and maintained by National Cancer Registry IrelandComments
The original article is available at https://link.springer.com/Published Citation
Sexton GP, Walsh P, Moriarty F, Lennon P, O'Neill JP. Survival in an era of organ preservation: an update on laryngeal cancer in Ireland. Eur Arch Otorhinolaryngol. 2023Publication Date
16 June 2023External DOI
PubMed ID
37326667Department/Unit
- Beaumont Hospital
- School of Pharmacy and Biomolecular Sciences
- Otolaryngology Head and Neck Surgery
Research Area
- Population Health and Health Services
Publisher
Springer Science and Business Media LLCVersion
- Published Version (Version of Record)
