Royal College of Surgeons in Ireland
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Survival in an era of organ preservation: an update on laryngeal cancer in Ireland

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journal contribution
posted on 2023-07-20, 09:32 authored by Gerard P Sexton, Paul Walsh, Frank MoriartyFrank Moriarty, Paul Lennon, James Paul O'NeillJames Paul O'Neill

Background: Laryngeal cancer epidemiology has changed in recent years, with falling incidence observed internationally. Organ preservation therapies have revolutionised management, though some patients may be unsuitable and survival was noted to fall in the 2000s. This study examines trends in laryngeal cancer in Ireland. 

Methods: A retrospective cohort study of National Cancer Registry of Ireland data from 1994 to 2014. 

Results: From a cohort of 2651, glottic disease was most common (62%, n = 1646). Incidence rose to 3.43 cases/100,000/year for 2010–2014. 5-year disease-specific survival (DSS) was 60.6% and did not change significantly over time. Overall survival (OS) for T3 disease managed with primary radiotherapy was similar to primary surgery (HR 0.98, p = 0.9). DSS for T3 disease improved with primary radiotherapy (HR 0.72, p = 0.045). 

Conclusion: Incidence of laryngeal cancer in Ireland rose despite international trends, while survival changed little. Radiotherapy improves DSS for T3 disease but does not improve OS, possibly secondary to poor organ function post-radiotherapy.


Open Access funding provided by the IReL Consortium


Data Availability Statement

Stored and maintained by National Cancer Registry Ireland


The original article is available at

Published Citation

Sexton GP, Walsh P, Moriarty F, Lennon P, O'Neill JP. Survival in an era of organ preservation: an update on laryngeal cancer in Ireland. Eur Arch Otorhinolaryngol. 2023

Publication Date

16 June 2023

PubMed ID



  • Beaumont Hospital
  • School of Pharmacy and Biomolecular Sciences
  • Otolaryngology Head and Neck Surgery

Research Area

  • Population Health and Health Services


Springer Science and Business Media LLC


  • Published Version (Version of Record)