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Systematic review and meta-analysis of the prevalence of cognitive impairment no dementia (CIND) in the first year post-stroke

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posted on 08.12.2021, 14:38 authored by Eithne SextonEithne Sexton, Affraic Mcloughlin, David WilliamsDavid Williams, Niamh Merriman, Nora Donnelly, Daniela Rohde, Anne HickeyAnne Hickey, Maev-Ann Wren, Kathleen BennettKathleen Bennett
Introduction: Increasing attention is being paid to interventions for cognitive impairment (CI) post-stroke, including for CI that does not meet dementia criteria. The aim of this paper was to conduct a systematic review and meta-analysis of the prevalence of cognitive impairment no dementia (CIND) within one year post-stroke.
Patients and methods: Pubmed, EMBASE and PsychInfo were searched for papers published in English in 1995–2017. Included studies were population or hospital-based cohort studies for first-ever/recurrent stroke, assessing CIND using standardised criteria at 1–12 months post-stroke. Abstracts were screened, followed by full text review of potentially relevant articles. Data were extracted using a standard form, and study quality was appraised using the Crowe Critical Appraisal Tool. A pooled prevalence of CIND with 95% confidence intervals (CI) was estimated using random-effects meta-analysis. Heterogeneity was measured using the I2 statistic.
Results: A total of 7000 abstracts were screened, followed by 1028 full text articles. Twenty-three articles were included in the systematic review, and 21 in the meta-analysis. The pooled CIND prevalence was 38% [95% CI = 32–43%] (I2=92.5%, p < 0.01). Study quality emerged as one source of heterogeneity. The five studies with the highest quality scores had no heterogeneity (I2=0%, p = 0.99), with a similar pooled prevalence (39%, 95%CI = 35–42%). Other sources of heterogeneity were stroke type, inclusion of pre-stroke CI, and age at assessment time.
Discussion and conclusion: Meta-analysis of available studies indicates that in the first year post-stroke, 4 in 10 patients display a level of cognitive impairment that does not meet the criteria for dementia.

Funding

Health Research Board grant no. ICE 2015-1048

Health Research Board award RL-15–1579

History

Comments

The original article is available at https://journals.sagepub.com

Published Citation

Sexton E et al. Systematic review and meta-analysis of the prevalence of cognitive impairment no dementia in the first year post-stroke. Eur Stroke J. 2019 ;4(2):160-171.

Publication Date

16 January 2019

PubMed ID

31259264

Department/Unit

  • Health Psychology
  • Beaumont Hospital
  • Data Science Centre
  • Medicine

Research Area

  • Neurological and Psychiatric Disorders
  • Population Health and Health Services
  • Vascular Biology

Publisher

SAGE Publications

Version

  • Accepted Version (Postprint)