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TLR3 Sensing of Viral Infection

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journal contribution
posted on 2022-03-30, 13:20 authored by F Dunlevy, Noel G McElvaneyNoel G McElvaney, Catherine GreeneCatherine Greene

Viral infection is detected by the innate immune system which mounts a rapid semi-selective defence involving inflammation and production of type 1 interferons. Several sensors, both cell surface and intracellular, exist to detect different types of viral motifs. Double-stranded RNA viruses and dsRNA replication intermediates are detected by tolllike receptor 3 (TLR3) as well as by retinoid-inducible gene 1 (RIG-I) like receptors. Binding of dsRNA or its synthetic analogue poly I:C to TLR3 recruits the adaptor protein TRIF and stimulates distinct pathways leading to activation of interferon regulatory factor (IRF) and NF-KB. Here, we review the signalling cascades initiated by TLR3 and the modulation of these pathways.



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Published Citation

Dunlevy F, McElvaney NG and Greene CM. TLR3 Sensing of Viral Infection. The Open Infectious Diseases Journal, 2010, 4, 1-10.

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  • Beaumont Hospital
  • Medicine

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