Targeting IRFs by ubiquitination: regulating antiviral responses.
journal contributionposted on 2019-11-22, 16:19 authored by Rowan Higgs, Caroline A. Jefferies
The IRF [IFN (interferon) regulatory factor] family of transcription factors control many cellular processes, including induction of key antiviral cytokines, type I IFNs, following viral infection. Recent studies have revealed several endogenous and viral proteins involved in ubiquitin-mediated regulation of IRF activity and thus having an impact on type I IFN signalling. Through the ubiquitin pathway, these proteins can manipulate the antiviral response either by initiating proteasomal degradation of the IRFs or, in contrast, by promoting activation of the IRFs.
CommentsThis article is also available at http://www.biochemsoctrans.org/bst/036/0453/bst0360453.htm
Published CitationHiggs R, Jefferies CA. Targeting IRFs by ubiquitination: regulating antiviral responses. Biochemical Society Transactions 2008;36(3):453-8.
- School of Pharmacy and Biomolecular Sciences