Royal College of Surgeons in Ireland
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Targeting SARS-CoV-2-platelet interactions in COVID-19 and vaccine-related thrombosis.

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journal contribution
posted on 2021-08-04, 10:41 authored by Dermot CoxDermot Cox
It is clear that COVID-19 is more than a pneumonia and is associated with a coagulopathy and multi-organ failure. While the use of anti-coagulants does reduce the incidence of pulmonary emboli, it does not help with survival. This suggests that the coagulopathy is more likely to be platelet-driven rather than thrombin-driven. There is significant evidence to suggest that SARS-CoV-2 virions directly interact with platelets to trigger activation leading to thrombocytopenia and thrombosis. I propose a model of multiple interactions between SARS-CoV-2 and platelets that has many similarities to that with Staphylococcus aureus and Dengue virus. As platelet activation and thrombosis are major factors in poor prognosis, therapeutics that target the platelet-SARS-CoV-2 interaction have potential in treating COVID-19 and other virus infections.



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Published Citation

Cox D. Targeting SARS-CoV-2-platelet interactions in COVID-19 and vaccine-related thrombosis. Front Pharmacol. 2021;12:708665.

Publication Date

5 July 2021

PubMed ID



  • School of Pharmacy and Biomolecular Sciences

Research Area

  • Immunity, Infection and Inflammation
  • Vascular Biology


Frontiers Media SA


  • Published Version (Version of Record)