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Targeting neutrophil elastase in cystic fibrosis.

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journal contribution
posted on 17.12.2021, 18:03 authored by Emer Kelly, Catherine GreeneCatherine Greene, Noel G McElvaneyNoel G McElvaney

BACKGROUND: Cystic fibrosis (CF) is a lethal hereditary disease characterised by neutrophil-dominated lung inflammation. These abundant neutrophils produce neutrophil elastase (NE), a destructive serine protease that has direct actions on extracellular matrix proteins and has a role in the host response to inflammation and infection.

OBJECTIVE: This review examines the prospect of developing novel therapies for CF by targeting NE. The authors explore the functions of NE and of naturally-occurring and synthetic NE inhibitors.

METHODS: A literature search was conducted exploring the functions of NE and inhibitors of NE; naturally occurring and synthetic.

CONCLUSIONS: Targeting NE in CF offers therapeutic potential, but optimal inhibitors that can be delivered safely and effectively to the lung are still under development.

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The Version of Scholarly Record of this Article is published Expert Opinion on Therapeutic Targets 2008, available online at: http://www.tandfonline.com/ DOI: 10.1517/14728222.12.2.145

Published Citation

Kelly E, Greene CM, McElvaney NG. Targeting neutrophil elastase in cystic fibrosis. Expert Opinion on Therapeutic Targets. 2008;12(2):145-57.

Publication Date

2008-02-01

PubMed ID

18208364

Department/Unit

  • Beaumont Hospital
  • Medicine

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