Temporal cortex morphology in mesial temporal lobe epilepsy patients and their asymptomatic siblings
journal contributionposted on 11.11.2021, 15:55 by Saud Alhusaini, Christopher D Whelan, Colin P Doherty, Norman DelantyNorman Delanty, Mary FitzsimonsMary Fitzsimons, Gianpiero CavalleriGianpiero Cavalleri
Temporal cortex abnormalities are common in patients with mesial temporal lobe epilepsy due to hippocampal sclerosis (MTLE+HS) and believed to be relevant to the underlying mechanisms. In the present study, we set out to determine the familiarity of temporal cortex morphologic alterations in a cohort of MTLE+HS patients and their asymptomatic siblings. A surface-based morphometry (SBM) method was applied to process MRI data acquired from 140 individuals (50 patients with unilateral MTLE+HS, 50 asymptomatic siblings of patients, and 40 healthy controls). Using a region-of-interest approach, alterations in temporal cortex morphology were determined in patients and their asymptomatic siblings by comparing with the controls. Alterations in temporal cortex morphology were identified in MTLE+HS patients ipsilaterally within the anterio-medial regions, including the entorhinal cortex, parahippocampal gyrus, and temporal pole. Subtle but similar pattern of morphology changes with a medium effect size were also noted in the asymptomatic siblings. These localized alterations were related to volume loss that appeared driven by shared contractions in cerebral cortex surface area. These findings indicate that temporal cortex morphologic alterations are common to patients and their asymptomatic siblings and suggest that such localized traits are possibly heritable.
Science Foundation Ireland Research Frontiers Programme award 08/RFP/GEN1538
CommentsThis is a pre-copyedited, author-produced PDF of an article accepted for publication in Cerebral Cortex following peer review. The version of record Alhusaini S, Whelan CD, Doherty CP, Delanty N, Fitzsimons M, Cavalleri GL. Temporal cortex morphology in mesial temporal lobe epilepsy patients and their asymptomatic siblings. Cereb Cortex. 2016;26(3):1234-41 is available online at: https://academic.oup.com/cercor/article/26/3/1234/2367287
Published CitationAlhusaini S, Whelan CD, Doherty CP, Delanty N, Fitzsimons M, Cavalleri GL. Temporal cortex morphology in mesial temporal lobe epilepsy patients and their asymptomatic siblings. Cereb Cortex. 2016;26(3):1234-41.
Publication Date9 January 2015
- Beaumont Hospital
- School of Pharmacy and Biomolecular Sciences
- Neurological and Psychiatric Disorders
PublisherOxford University Press (OUP)
- Accepted Version (Postprint)
Temporal LobeEpilepsy, Temporal LobeGenetic Predisposition to DiseaseMagnetic Resonance ImagingOrgan SizeSiblingsasymptomatic siblingsheritabilityhippocampal sclerosistemporal lobe epilepsyExperimental PsychologyNeurosciencesPsychologyCognitive SciencesTemporal cortex abnormalitiesMesial Temporal Lobeepilepsy