Royal College of Surgeons in Ireland
The ENIGMA-Epilepsy working group....pdf (6.58 MB)

The ENIGMA-Epilepsy working group: Mapping disease from large data sets

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journal contribution
posted on 2021-04-12, 08:35 authored by Sanjay M Sisodiya, Christopher Whelan, Gianpiero CavalleriGianpiero Cavalleri, ENIGMA Consortium Epilepsy Working Group
Epilepsy is a common and serious neurological disorder, with many different constituent conditions characterized by their electro clinical, imaging, and genetic features. MRI has been fundamental in advancing our understanding of brain processes in the epilepsies. Smaller-scale studies have identified many interesting imaging phenomena, with implications both for understanding pathophysiology and improving clinical care. Through the infrastructure and concepts now well-established by the ENIGMA Consortium, ENIGMA-Epilepsy was established to strengthen epilepsy neuroscience by greatly increasing sample sizes, leveraging ideas and methods established in other ENIGMA projects, and generating a body of collaborating scientists and clinicians to drive forward robust research. Here we review published, current, and future projects, that include structural MRI, diffusion tensor imaging (DTI), and resting state functional MRI (rsfMRI), and that employ advanced methods including structural covariance, and event-based modeling analysis. We explore age of onset- and duration-related features, as well as phenomena-specific work focusing on particular epilepsy syndromes or phenotypes, multimodal analyses focused on understanding the biology of disease progression, and deep learning approaches. We encourage groups who may be interested in participating to make contact to further grow and develop ENIGMA-Epilepsy.


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Published Citation

Sisodiya SM. et al. The ENIGMA-Epilepsy working group: mapping disease from large data sets. Hum Brain Mapp. 2020;43(1):113–28

Publication Date

29 May 2020

PubMed ID



  • FutureNeuro Centre
  • School of Pharmacy and Biomolecular Sciences

Research Area

  • Neurological and Psychiatric Disorders




  • Published Version (Version of Record)