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The future of Kawasaki disease diagnosis: liquid biopsy may hold the key

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posted on 2024-11-25, 17:22 authored by Kasturi Markandran, Kristine Nicole Mendoza Clemente, Elena Tan, Karan Attal, Qiao Zhi Chee, Christine Cheung, Ching Kit Chen

Kawasaki disease (KD) is a febrile illness characterised by systemic inflammation of small- and medium-sized blood vessels, which commonly occurs in young children. Although self-limiting, there is a risk of developing coronary artery lesions as the disease progresses, with delay in diagnosis and treatment. Unfortunately, the diagnosis of KD continues to remain a clinical dilemma. Thus, this article not only summarises the key research gaps associated with KD, but also evaluates the possibility of using circulating endothelial injury biomarkers, such as circulating endothelial cells, endothelial microparticles and vascular endothelial cell-free DNA, as diagnostic and prognostic tools for KD: a "liquid biopsy" approach. The challenges of translating liquid biopsies to use in KD and the opportunities for improvement in its diagnosis and management that such translation may provide are discussed. The use of endothelial damage markers, which are easily obtained via blood collection, as diagnostic tools is promising, and we hope this will be translated to clinical applications in the near future. 

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The original article is available at https://www.mdpi.com/

Published Citation

Markandran K. et al. The future of Kawasaki Disease diagnosis: liquid biopsy may hold the key. Int J Mol Sci. 2024;25(15):8062.

Publication Date

24 July 2024

PubMed ID

39125631

Department/Unit

  • Undergraduate Research

Publisher

MDPI

Version

  • Published Version (Version of Record)