The impact of COVID-19 lockdown on infants’ coronavirus exposure and routine healthcare access in Ireland: the CORAL birth cohort study at 6 months.
The public health strategy during the SARS-CoV-2 (COVID-19) pandemic of 2020–2021 led to profound changes in social behaviour, affecting not only familial but also wider social interactions. These changes may have altered viral and bacterial interchange.
A significantly decreased diversity of gut and skin microbiota has been demonstrated inallergic individuals compared to non-allergic subjects. The CORAL study is a longitudinal study of the impact of the Coronavirus Pandemic on allergic and autoimmune dysregulation of infants born from March –May 2020, during Ireland’s first lockdown (Ireland formally entered national lockdown on March 27th 2020, though severe restrictions had been gradually escalated for the 2 weeks prior to that date. The first release of lockdown was on June 8th 2020). CORAL will follow children initially until they are 2 years old, with stool sampling at 6,12 and 24 months for microbiome diversity analysis and allergy testing and blood RNA and epigenomic testing at 12 and 24 months
Funding
Temple Street Hospital Foundation, Dublin, Ireland
Clemens Von Pirquet Foundation, Geneva, Switzerland
History
Comments
"This is the peer reviewed version of the following article: Lawler M, Franklin R, McCallion N, Byrne AM, Fitzsimons J, Kinoshita M, White M, O'Mahony L, Hourihane J. The impact of COVID-19 lockdown on infants' coronavirus exposure and routine healthcare access in Ireland: The CORAL birth cohort study at 6 months. Pediatr Allergy Immunol. 2021;32(8):1876-1879., which has been published in final form at https://doi.org/10.1111/pai.13591. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."Published Citation
Lawler M, et al. The impact of COVID-19 lockdown on infants' coronavirus exposure and routine healthcare access in Ireland: the CORAL birth cohort study at 6 months. Pediatr Allergy Immunol. 2021;32(8):1876-1879.Publication Date
1 July 2021External DOI
PubMed ID
34197667Department/Unit
- Paediatrics
Publisher
John Wiley & Sons, Inc.Version
- Accepted Version (Postprint)
