The many faces of coronavirus disease 2019: COVID-19 and the liver.

The coronavirus disease 2019 (COVID-19) continues to pose unprecedented challenges to patients, physicians, and healthcare setups alike. Its numerous clinical ramifications remain unabated, with increasing medical literature establishing its involvement in the onset and perpetuation of a myriad of extrapulmonary manifestations. Of these extrapulmonary manifestations, hepatic impairment has been extensively reported by researchers and clinicians. While hepatic impairment is noted to be an established possible sequel of a COVID-19 infection, its pathophysiological basis remains unclear. In order to devise effective, all-encompassing management protocols, it is imperative to thoroughly elucidate the pathophysiology and clinical manifestations of COVID-19 plays in causing liver injury. Herein, we aim to review the literature to date on hepatic manifestations of COVID-19 in patients with no pre-existing liver disease, patients with chronic liver disease and patients with liver transplantation.