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The role of anti-inflammatory drugs and nanoparticle-based drug delivery models in the management of ischemia-induced heart failure

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journal contribution
posted on 19.08.2021, 15:44 by Kathryn E Haley, Talal Almas, Saeed Shoar, Shan Shaikh, Maimoona Azhar, Faisal Habib Cheema, Aamir HameedAamir Hameed
Ongoing advancements in the treatment of acute myocardial infarction (MI) have significantly decreased MI related mortality. Consequently, the number of patients experiencing post-MI heart failure (HF) has continued to rise. Infarction size and the extent of left ventricular (LV) remodeling are largely determined by the extent of ischemia at the time of myocardial injury. In the setting of MI or acute phase of post-MI LV remodeling, anti-inflammatory drugs including intravenous immunoglobulin (IVIG) and Pentoxifylline have shown potential efficacy in preventing post-MI remodeling in-vitro and in some clinical trials. However, systemic administration of anti-inflammatory drugs are not without their off-target side effects. Herein, we explore the clinical feasibility of targeted myocardial delivery of anti-inflammatory drugs via biodegradable polymers, liposomes, hydrogels, and nano-particle based drug delivery models (NDDM) based on existing pre-clinical and clinical models. We summarize the barriers to clinical application of targeted anti-inflammatory delivery post-MI, including challenges in achieving sufficient retention and distribution, as well as the potential need for multiple dosing. Collectively, we suggest that localized delivery of anti-inflammatory agents to the myocardium using NDDM is a promising approach for successful treatment of ischemic HF. Future studies will be instrumental in determining the most effective target and delivery modalities for orchestrating NDDM-mediated treatment of HF.

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Comments

The original article is available at https://www.sciencedirect.com/

Published Citation

Haley, KE. et al. The role of anti-inflammatory drugs and nanoparticle-based drug delivery models in the management of ischemia-induced heart failure. Biomed Pharmacother. 2021;142:112014

Publication Date

11 August 2021

PubMed ID

34391184

Department/Unit

  • Anatomy and Regenerative Medicine
  • School of Medicine
  • Undergraduate Research
  • Tissue Engineering Research Group (TERG)

Research Area

  • Biomaterials and Regenerative Medicine
  • Surgical Science and Practice

Publisher

Elsevier BV

Version

  • Published Version (Version of Record)