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Therapeutic Targeting of the Colorectal Tumor Stroma

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posted on 31.03.2020, 08:49 authored by Wolf Herman Fridman, Ian MillerIan Miller, Catherine Sautès-Fridman, Annette ByrneAnnette Byrne
Colorectal tumors have been classified based on histologic factors, genetic factors, and consensus molecular subtypes, all of which affect the tumor microenvironment. Elements of the tumor microenvironment serve as therapeutic targets and might be used as prognostic factors. For example, immune checkpoint inhibitors are used to treat tumors with microsatellite instability, and anti-angiogenic agents may be used in combination with other drugs to slow or inhibit tumor growth. We review the features of the colorectal tumor stroma that are associated with patient outcomes and discuss potential therapeutic agents that target these features.


Horizon 2020 Research and Innovation Programme (Grant Agreement No. 754923 “ COLOSSUS”)

Science Foundation Ireland grant 13/CDA/2183 ”COLOFORETELL’

Health Research Board grant ILP-POR-2019-066

WHF, CSF receive funding from INSERM, Université de Paris, Sorbonne University, CARPEM T8, the Labex Immuno-Oncology Excellence Program, Institut du Cancer (INCa), HTE Plan Cancer (C1608DS), and the Cartes d’Identité des Tumeurs (CIT) Program from the Ligue Nationale Contre le Cancer



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Fridman WH, Miller I, Sautes-Fridman C, Byrne AT. Therapeutic Targeting of the Colorectal Tumor Stroma. Gastroenterology. 2020;158(2):303-321

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