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Therapeutic effects of anti-diabetic drugs on traumatic brain injury

journal contribution
posted on 2024-06-12, 15:02 authored by Seyed Mehrad Razavi, Zahra Najafi Arab, Amirhossein Niknejad, Yasamin Hosseini, Abtin Fouladi, Saba Darban Khales, Mostafa Shahali, Saeideh Momtaz, Alexandra ButlerAlexandra Butler, Vasily N Sukhorukov, Tannaz Jamialahmadi, Amir Hossein Abdolghaffari, Amirhossein Sahebkar

Aims: In this narrative review, we have analyzed and synthesized current studies relating to the effects of anti-diabetic drugs on traumatic brain injury (TBI) complications.

Methods: Eligible studies were collected from Scopus, Google Scholar, PubMed, and Cochrane Library for clinical, in-vivo, and in-vitro studies published on the impact of anti-diabetic drugs on TBI.

Results: Traumatic brain injury (TBI) is a serious brain disease that is caused by any type of trauma. The pathophysiology of TBI is not yet fully understood, though physical injury and inflammatory events have been implicated in TBI progression. Several signaling pathways are known to play pivotal roles in TBI injuries, including Nuclear factor erythroid 2-related factor 2 (Nrf2), High mobility group box 1 protein/Nuclear factor kappa B (HMGB1/NF-κB), Adiponectin, Mammalian Target of Rapamycin (mTOR), Toll-Like Receptor (TLR), Wnt/β-catenin, Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT), Nod-like receptor protein3 (NLRP3) inflammasome, Phosphoglycerate kinase 1/Kelch-like ECH-associated protein 1 (PGK1/KEAP1)/Nrf2, and Mitogen-activated protein kinase (MAPK) . Recent studies suggest that oral anti-diabetic drugs such as biguanides, thiazolidinediones (TZDs), sulfonylureas (SUs), sodium-glucose cotransporter-2 inhibitors (SGLT2is), dipeptidyl peptidase-4 inhibitors (DPPIs), meglitinides, and alpha-glucosidase inhibitors (AGIs) could have beneficial effects in the management of TBI complications. These drugs may downregulate the inflammatory pathways and induce antioxidant signaling pathways, thus alleviating complications of TBI.

Conclusion: Based on this comprehensive literature review, antidiabetic medications might be considered in the TBI treatment protocol. However, evidence from clinical trials in patients with TBI is still warranted.

Funding

Russian Science Foundation (Grant # 23-65-10014)

History

Comments

The original article is available at https://www.sciencedirect.com/

Published Citation

Razavi SM, et al. Therapeutic effects of anti-diabetic drugs on traumatic brain injury. Diabetes Metab Syndr. 2024;18(2):102949

Publication Date

26 January 2024

PubMed ID

38308863

Department/Unit

  • RCSI Bahrain

Publisher

Elsevier BV

Version

  • Accepted Version (Postprint)