Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases.
journal contributionposted on 2022-03-08, 16:09 authored by Tidi HassanTidi Hassan, Paul J. McKiernan, Noel G McElvaneyNoel G McElvaney, Sally-Ann CryanSally-Ann Cryan, Catherine GreeneCatherine Greene
miRNAs are short, nonprotein coding RNAs that regulate target gene expression principally by causing translational repression and/or mRNA degradation. miRNAs are involved in most mammalian biological processes and have pivotal roles in controlling the expression of factors involved in basal and stimulus-induced signaling pathways. Considering their central role in the regulation of gene expression, miRNAs represent therapeutic drug targets. Here we describe how miRNAs are involved in the regulation of aspects of innate immunity and inflammation, what happens when this goes awry, such as in the chronic inflammatory lung diseases cystic fibrosis and asthma, and discuss the current state-of-the-art miRNA-targeted therapeutics.
Comments“This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Anti-infective Therapy. On 10th January 2014, available online: http://www.tandfonline.com/ https://doi.org/10.1586/eri.11.175
Published CitationHassan T, McKiernan PJ, McElvaney NG, Cryan SA, Greene CM. Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases. Expert Review of Anti-Infect Therapy. 201210(3):359-68.
- Beaumont Hospital
- School of Pharmacy and Biomolecular Sciences