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Thou shall not heal: overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment

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journal contribution
posted on 2024-01-26, 16:19 authored by Michael G Monaghan, Rajiv Borah, Charlotte Thomsen, Shane BrowneShane Browne

Diabetic foot ulcers (DFUs) are a devastating complication for diabetic patients that have debilitating effects and can ultimately lead to limb amputation. Healthy wounds progress through the phases of healing leading to tissue regeneration and restoration of the barrier function of the skin. In contrast, in diabetic patients dysregulation of these phases leads to chronic, non-healing wounds. In particular, unresolved inflammation in the DFU microenvironment has been identified as a key facet of chronic wounds in hyperglyceamic patients, as DFUs fail to progress beyond the inflammatory phase and towards resolution. Thus, control over and modulation of the inflammatory response is a promising therapeutic avenue for DFU treatment. This review discusses the current state-of-the art regarding control of the inflammatory response in the DFU microenvironment, with a specific focus on the development of biomaterials-based delivery strategies and their cargos to direct tissue regeneration in the DFU microenvironment. 

Funding

European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 10106728

flIMAGIN3D-DN Horizon Europe-MSCA-DN No. 10107350

European Foundation for the Study of Diabetes (EFSD) and Lily European Diabetes Research Programme 2022

Advanced Materials and Bioengineering Research (AMBER) Centre (SFI/12/RC/2278_P2)

European Regional Development Fund

PSRC and SFI Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine (lifETIME CDT), Grant Number EP/S02347X/1519

CÚRAM, an SFI Research Centre Designing The Next Generation of 'Smart' Medical Devices under a grant from Science Foundation Ireland (SFI)

European Regional Development Fund (ERDF) under grant number 13/RC/2073_P2

History

Data Availability Statement

No data was used for the research described in the article

Comments

The original article is available at https://www.sciencedirect.com/

Published Citation

Monaghan MG, Borah R, Thomsen C, Browne S. Thou shall not heal: overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment. Adv Drug Deliv Rev. 2023;203:115120.

Publication Date

25 October 2023

PubMed ID

37884128

Department/Unit

  • Amber (Advanced Material & Bioengineering Research) Centre
  • Tissue Engineering Research Group (TERG)
  • Anatomy and Regenerative Medicine

Publisher

Elsevier B.V.,

Version

  • Published Version (Version of Record)