Thou shall not heal: overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment
Diabetic foot ulcers (DFUs) are a devastating complication for diabetic patients that have debilitating effects and can ultimately lead to limb amputation. Healthy wounds progress through the phases of healing leading to tissue regeneration and restoration of the barrier function of the skin. In contrast, in diabetic patients dysregulation of these phases leads to chronic, non-healing wounds. In particular, unresolved inflammation in the DFU microenvironment has been identified as a key facet of chronic wounds in hyperglyceamic patients, as DFUs fail to progress beyond the inflammatory phase and towards resolution. Thus, control over and modulation of the inflammatory response is a promising therapeutic avenue for DFU treatment. This review discusses the current state-of-the art regarding control of the inflammatory response in the DFU microenvironment, with a specific focus on the development of biomaterials-based delivery strategies and their cargos to direct tissue regeneration in the DFU microenvironment.
Funding
European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 10106728
flIMAGIN3D-DN Horizon Europe-MSCA-DN No. 10107350
European Foundation for the Study of Diabetes (EFSD) and Lily European Diabetes Research Programme 2022
Advanced Materials and Bioengineering Research (AMBER) Centre (SFI/12/RC/2278_P2)
European Regional Development Fund
PSRC and SFI Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine (lifETIME CDT), Grant Number EP/S02347X/1519
CÚRAM, an SFI Research Centre Designing The Next Generation of 'Smart' Medical Devices under a grant from Science Foundation Ireland (SFI)
European Regional Development Fund (ERDF) under grant number 13/RC/2073_P2
History
Data Availability Statement
No data was used for the research described in the articleComments
The original article is available at https://www.sciencedirect.com/Published Citation
Monaghan MG, Borah R, Thomsen C, Browne S. Thou shall not heal: overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment. Adv Drug Deliv Rev. 2023;203:115120.Publication Date
25 October 2023External DOI
PubMed ID
37884128Department/Unit
- Amber (Advanced Material & Bioengineering Research) Centre
- Tissue Engineering Research Group (TERG)
- Anatomy and Regenerative Medicine
Publisher
Elsevier B.V.,Version
- Published Version (Version of Record)