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Towards the use of localised delivery strategies to counteract cancer therapy–induced cardiotoxicities.

journal contribution
posted on 15.03.2021, 10:05 by David S Monahan, Talal Almas, Robert Wyile, Faisal H Cheema, Garry Duffy, Aamir Hameed
Cancer therapies have significantly improved cancer survival; however, these therapies can often result in undesired side effects to off target organs. Cardiac disease ranging from mild hypertension to heart failure can occur as a result of cancer therapies. This can warrant the discontinuation of cancer treatment in patients which can be detrimental, especially when the treatment is effective. There is an urgent need to mitigate cardiac disease that occurs as a result of cancer therapy. Delivery strategies such as the use of nanoparticles, hydrogels, and medical devices can be used to localise the treatment to the tumour and prevent off target side effects. This review summarises the advancements in localised delivery of anti-cancer therapies to tumours. It also examines the localised delivery of cardioprotectants to the heart for patients with systemic disease such as leukaemia where localised tumour delivery might not be an option.

Funding

Irish Research Council Government of Ireland Postgraduate Scholarship (GOIPG/2017/927)

College of Medicine, Nursing, and Health Sciences at the National University of Ireland Galway

Fulbright Enterprise Ireland Program

History

Comments

This is a post-peer-review, pre-copyedit version of an article published in Drug Delivery and Translational Research. The final authenticated version is available online at: https://doi.org/10.1007/s13346-020-00885-3

Published Citation

Monahan DS, Almas T, Wyile R, Cheema FH, Duffy GP, Hameed A. Towards the use of localised delivery strategies to counteract cancer therapy-induced cardiotoxicities. Drug Delivery and Translational Research. 2021.

Publication Date

15 January 2021

PubMed ID

33449342

Department/Unit

  • Anatomy and Regenerative Medicine
  • RCSI Tissue Engineering Group (TERG)
  • School of Medicine
  • Undergraduate Research

Research Area

  • Surgical Science and Practice
  • Biomaterials and Regenerative Medicine

Publisher

Springer

Version

  • Published Version (Version of Record)