Geoghegan et al, 2022.pdf (4.19 MB)
Use of a novel “Split” ventilation system in bench and porcine modeling of acute respiratory distress syndrome
journal contributionposted on 2023-01-09, 17:21 authored by Pierce GeogheganPierce Geoghegan, Jennifer ClarkeJennifer Clarke, Grace HoganGrace Hogan, Aoife Keogh, Hannah Marsh, Karen Donnelly, Natalie McEvoyNatalie McEvoy, Aoife Doolan, Stephen MaddenStephen Madden, Ignacio Martin-Loeches, Michael Power, John G Laffey, Gerard CurleyGerard Curley
Split ventilation (using a single ventilator to ventilate multiple patients) is technically feasible. However, connecting two patients with acute respiratory distress syndrome (ARDS) and differing lung mechanics to a single ventilator is concerning. This study aimed to: (1) determine functionality of a split ventilation system in benchtop tests, (2) determine whether standard ventilation would be superior to split ventilation in a porcine model of ARDS and (3) assess usability of a split ventilation system with minimal specific training. The functionality of a split ventilation system was assessed using test lungs. The usability of the system was assessed in simulated clinical scenarios. The feasibility of the system to provide modified lung protective ventilation was assessed in a porcine model of ARDS (n = 30). In bench testing a split ventilation system independently ventilated two test lungs under conditions of varying compliance and resistance. In usability tests, a high proportion of naïve operators could assemble and use the system. In the porcine model, modified lung protective ventilation was feasible with split ventilation and produced similar respiratory mechanics, gas exchange and biomarkers of lung injury when compared to standard ventilation. Split ventilation can provide some elements of lung protective ventilation and is feasible in bench testing and an in vivo model of ARDS.
Enterprise Ireland, Dublin, Ireland
Health Research Board (Ireland) Emerging Clinician Scientist Award (ESCA ESCA-2020-009)
CommentsThe original article is available at https://physoc.onlinelibrary.wiley.com/
Published CitationGeoghegan P. et al. Use of a novel "Split" ventilation system in bench and porcine modeling of acute respiratory distress syndrome. Physiol Rep. 2022;10(17):e15452.
Publication Date9 September 2022
- Anaesthetics and Critical Care
- Beaumont Hospital
- Data Science Centre
- Neurological and Psychiatric Disorders
- Gynaecology, Obstetrics and Perinatal Health
- Published Version (Version of Record)
LungAnimalsRespiration, ArtificialRespirationRespiratory MechanicsRespiratory Distress Syndromeacute lung injuryacute respiratory distress syndromelung protective ventilationsplit ventilationClinical SciencesMedical PhysiologyARDSbenchtop testsCOVID-19CoronavirusSARS-CoV-2PandemicsInfectious DiseasesRespiratory Diseases