Royal College of Surgeons in Ireland
Value of Deprescribing Commentary_accepted.docx (65.82 kB)

Value assessment of deprescribing interventions: suggestions for improvement

Download (65.82 kB)
journal contribution
posted on 2023-11-16, 14:22 authored by Anna Hung, Jinjiao Wang, Frank MoriartyFrank Moriarty, Veena Manja, Tesfahun Eshetie, Henok Getachew Tegegn, Timothy S. Anderson, Thomas R. Radomski, Michael A. Steinman

Polypharmacy and the inappropriate use of medications is a prevalent, potentially harmful, and costly problem that can be addressed by deprescribing, which is defined as the “systematic process of identifying and discontinuing drugs when existing or potential harms outweigh existing or potential benefits within the context of an individual patient's care goals, functional status, life expectancy, values, and preferences.”1 Evidence from clinical trials has demonstrated that deprescribing interventions can reduce the number of potentially inappropriate medications; yet the next question of whether such interventions are cost-effective is often unanswered.2 In this commentary, we describe current practices in assessing the value of deprescribing interventions and their limitations, and then suggest potential improvements. 


Alliance for Home Health Quality and Innovation

Durham Center of Innovation to Accelerate Discovery and Practice Transformation. Grant Number: CIN 13-410

Health Services Research and Development. Grant Numbers: IIR 19-089, IK2 HX003359

National Institute on Aging. Grant Numbers: K23AG061217, K24AG049057, P30AG044281, K76AG074878, R24AG064025



This is the peer reviewed version of the following article: Hung A, et al. Value assessment of deprescribing interventions: Suggestions for improvement. J Am Geriatr Soc. 2023;71(6):2023-2027., which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

Published Citation

Hung A, et al. Value assessment of deprescribing interventions: suggestions for improvement. J Am Geriatr Soc. 2023;71(6):2023-2027.

Publication Date

21 February 2023

PubMed ID



  • School of Pharmacy and Biomolecular Sciences

Research Area

  • Population Health and Health Services




  • Accepted Version (Postprint)

Usage metrics

    Royal College of Surgeons in Ireland


    Ref. manager