Royal College of Surgeons in Ireland
Vitamin D in schizophrenia and depression_ a clinical review.pdf (228.09 kB)
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Vitamin D in schizophrenia and depression: a clinical review

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journal contribution
posted on 2021-12-17, 09:57 authored by John LallyJohn Lally, Fiona P Gaughran

Evidence from preclinical and clinical studies supports a role for vitamin D deficiency in many mental disorders. In this review, we discuss the role of vitamin D in the aetiology and treatment of schizophrenia and depression and their physical health comorbidities. Although observational studies support a potential association between vitamin D and schizophrenia and depression, sufficient high-quality evidence from clinical trials does not yet exist to establish a place for vitamin D supplementation in optimising clinical response or promoting physical health. Completed randomised controlled trials are needed to provide insights into the efficacy and safety of vitamin D in the management of mental disorders.



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Published Citation

Lally J, Gaughran, F. Vitamin D in schizophrenia and depression: A clinical review. BJPsych Advances. 2019;25(4):240-248.

Publication Date

17 April 2019


  • Psychiatry

Research Area

  • Neurological and Psychiatric Disorders


Cambridge University Press


  • Accepted Version (Postprint)