Modulators of neuronal cell death in epilepsy.doc (182 kB)

Modulators of neuronal cell death in epilepsy

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posted on 28.04.2021, 16:00 by David Henshall, Brona Murphy
Experimental and human data have shown that certain seizures cause damage to brain. Such neuronal loss may result in cognitive impairments and perhaps contribute to the development or phenotype of emergent epilepsy. Recent work using genetically modified mice, Tat protein transduction, and viral vectors has shown functional effects of manipulating Bcl-2 and Bcl-w, heat shock proteins, caspases, and their regulators and endonucleases on neuronal death in models of status epilepticus. Ancillary effects on seizure induction and excitability thresholds have emerged for several genes suggesting additional properties of therapeutic potential. Differing hippocampal expression of certain Bcl-2 family genes, elevated endoplasmic reticulum stress chaperones, and death receptor pathway modulation in epilepsy patients support clinical relevance of this focus. These findings may yield potentially valuable adjunctive neuroprotective or anti-epileptogenic strategies.

Funding

Science Foundation Ireland

Health Research Board Ireland

Wellcome Trust

Marie Curie Actions

National Institutes of Health

History

Comments

The original article is available https://www.sciencedirect.com

Published Citation

Henshall DC, Murphy BM. Modulators of neuronal cell death in epilepsy. Current Opinion in Pharmacology. 2008;8(1):75-81.

Publication Date

10 September 2007

PubMed ID

17827063

Department/Unit

  • Physiology and Medical Physics

Research Area

  • Neurological and Psychiatric Disorders

Publisher

Elsevier

Version

  • Submitted Version (Preprint)

Licence

Exports