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Nicola Judge Thesis- Final.pdf (13.61 MB)

Development of Ring Opening Mini-Emulsion Polymerisation of N-Carboxyanhydride Monomers for the Formation of Polypeptide Nanoparticles

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posted on 2023-04-26, 12:34 authored by Nicola Judge

The aim of this work was to increase the understanding and library of polypeptide  nanoparticles synthesised by ring-opening mini-emulsion polymerisation of N-Carboxyanhydride amino acid monomers. Initially the conditions of the emulsion will be  investigated in order to afford facile tuneability of the system. Taking inspiration from  previous reports stereochemistry, nature of the amino acid polymerised and theoretical  secondary structure was also examined with the aim to achieving statistical differences in  size and morphology. Employing the techniques previously described any initial differences  observed are to be thoroughly investigated in order to eliminate any bias encountered by  one technique. Once the limitations and boundaries of the basis system are fully understood  it should enable the application of functionalised amino acids to afford nanoparticles with defined core and shell functionality. It is thought that this alongside tuning of the core density  through solid content and core to surfactant ratio by mass will afford a highly versatile  delivery system of active compounds.  

Funding

2390B

History

First Supervisor

Prof. Andreas Heise

Second Supervisor

Dr. Marco Monopoli

Comments

Submitted for the Award of Doctor of Philosophy to RCSI University of Medicine and Health Sciences, 2022

Published Citation

Judge NG,. Development of Ring Opening Mini-Emulsion Polymerisation of N-Carboxyanhydride Monomers for the Formation of Polypeptide Nanoparticles. [PhD Thesis] Dublin: RCSI University of Medicine and Health Sciences; 2022

Degree Name

  • Doctor of Philosophy (PhD)

Date of award

2022-11-30

Programme

  • Doctor of Philosophy (PhD)

Research Area

  • Chemistry and Pharmaceutical Sciences

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