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Innovative Biomimetic Collagen-based Scaffolds for Enhanced and Longer Lasting Cartilage Repair

thesis
posted on 23.03.2022, 15:55 authored by Claudio IntiniClaudio Intini

This thesis has led to the development of a novel highly porous collagen-based scaffold for enhanced and longer lasting cartilage repair, by incorporating type II collagen (CII) and hyaluronic acid (HyA) within a type I collagen (CI) framework. This newly developed CI/II-HyA scaffold biomaterial has demonstrated to effectively regenerate high-quality cartilage-like tissue in vitro with promise to provide stable and long-term performance in vivo for cartilage repair. Furthermore, this platform was successfully adapted to deliver gene therapy, specifically involving the development of an innovative microRNA-activated scaffold which offers greater control of the mesenchymal stem cell (MSC) chondrogenic processes, and possibly enhanced cartilage repair in the clinic. These scaffold systems show good promise for simple and effective “off the shelf” application in patients for cartilage repair.

Funding

European Union’s Horizon 2020 research and innovation programme under Marie Sklodowska-Curie grant agreement No 721432.

European Research Council (ERC) Advanced Grant n°788753 (ReCaP)

History

First Supervisor

Prof. Fergal J. O'Brien

Second Supervisor

Dr. John P. Gleeson

Comments

Submitted for the degree of Doctor of Philosophy from the Royal College of Surgeons in Ireland in 2021

Published Citation

Intini, C., Innovative Biomimetic Collagen-based Scaffolds for Enhanced and Longer Lasting Cartilage Repair [PhD Thesis]. Dublin: Royal College of Surgeons in Ireland; 2021

Degree Name

Doctor of Philosophy (PhD)

Date of award

30/11/2021

Programme

  • Doctor of Philosophy (PhD)

Research Area

  • Biomaterials and Regenerative Medicine