File(s) under embargo
until file(s) become available
Innovative Biomimetic Collagen-based Scaffolds for Enhanced and Longer Lasting Cartilage Repair
This thesis has led to the development of a novel highly porous collagen-based scaffold for enhanced and longer lasting cartilage repair, by incorporating type II collagen (CII) and hyaluronic acid (HyA) within a type I collagen (CI) framework. This newly developed CI/II-HyA scaffold biomaterial has demonstrated to effectively regenerate high-quality cartilage-like tissue in vitro with promise to provide stable and long-term performance in vivo for cartilage repair. Furthermore, this platform was successfully adapted to deliver gene therapy, specifically involving the development of an innovative microRNA-activated scaffold which offers greater control of the mesenchymal stem cell (MSC) chondrogenic processes, and possibly enhanced cartilage repair in the clinic. These scaffold systems show good promise for simple and effective “off the shelf” application in patients for cartilage repair.
European Union’s Horizon 2020 research and innovation programme under Marie Sklodowska-Curie grant agreement No 721432.
European Research Council (ERC) Advanced Grant n°788753 (ReCaP)
First SupervisorProf. Fergal J. O'Brien
Second SupervisorDr. John P. Gleeson
CommentsSubmitted for the degree of Doctor of Philosophy from the Royal College of Surgeons in Ireland in 2021
Published CitationIntini, C., Innovative Biomimetic Collagen-based Scaffolds for Enhanced and Longer Lasting Cartilage Repair [PhD Thesis]. Dublin: Royal College of Surgeons in Ireland; 2021
Degree NameDoctor of Philosophy (PhD)
Date of award30/11/2021
- Doctor of Philosophy (PhD)
- Biomaterials and Regenerative Medicine