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PhD Thesis Roberta Pacifico.pdf (12.35 MB)

Pyridine-Based 1,2,3-Triazoles: A New Class of Potential KAT2A Inhibitors and Scaffolds for C-H Activation and Catalysis

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posted on 2023-01-31, 11:45 authored by Roberta Pacifico

Aim: This thesis is focused on the synthesis of new pyridine-based 1,2,3-triazoles to be employed as potential scaffolds for drug discovery and for diverse applications in organic chemistry such as C-H activation and organocatalysis. In particular, this thesis will focus on the biological importance of the synthesised pyridine-based triazoles as potential inhibitors of the KAT2A protein and on their transformations through copper- and palladium- catalysed C-H activations into potentially active compounds. Moreover, it is also described the attempted synthesis of proline-based organocatalysts, enclosing a triazole moiety in their backbone, that will be further evaluated for future applications in organocatalytic reactions such as aldol condensations, Mannich and Michael reactions.

History

First Supervisor

Prof. Mauro F.A.Adamo

Comments

Submitted for the Award of Doctor of Philosophy to RCSI University of Medicine and Health Sciences, 2022

Published Citation

Pacifico R,. Pyridine-Based 1,2,3-Triazoles: A New Class of Potential KAT2A Inhibitors and Scaffolds for C-H Activation and Catalysis. [PhD Thesis] Dublin: RCSI University of Medicine and Health Sciences; 2022

Degree Name

  • Doctor of Philosophy (PhD)

Date of award

2022-11-30

Programme

  • Doctor of Philosophy (PhD)

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