Pyridine-Based 1,2,3-Triazoles: A New Class of Potential KAT2A Inhibitors and Scaffolds for C-H Activation and Catalysis

Aim: This thesis is focused on the synthesis of new pyridine-based 1,2,3-triazoles to be employed as potential scaffolds for drug discovery and for diverse applications in organic chemistry such as C-H activation and organocatalysis. In particular, this thesis will focus on the biological importance of the synthesised pyridine-based triazoles as potential inhibitors of the KAT2A protein and on their transformations through copper- and palladium- catalysed C-H activations into potentially active compounds. Moreover, it is also described the attempted synthesis of proline-based organocatalysts, enclosing a triazole moiety in their backbone, that will be further evaluated for future applications in organocatalytic reactions such as aldol condensations, Mannich and Michael reactions.