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Vaping THC-O acetate: potential for another EVALI epidemic

journal contribution
posted on 2023-04-13, 15:37 authored by Neal L Benowitz, Christopher Havel, Peyton Jacob, Donal O'SheaDonal O'Shea, Dan WuDan Wu, Jefferson Fowles

This brief report is to alert the public health community to the confirmed presence of Δ8-THC-O acetate in commercially available vaping products and the potential risk of pulmonary toxicity from vaping THC-O. The impetus for this study was the presence of the aryl acetate moiety in THC-O. Mass spectrometry (MS) evidence and activation energy (AE) calculations indicating that vaping of THC-O is likely to generate ketene, a suspected cause of lung injury, are provided. 

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The original article is available at https://link.springer.com/

Published Citation

Benowitz NL. et al. Vaping THC-O acetate: potential for another EVALI epidemic. J Med Toxicol. 2023;19(1):37-39.

Publication Date

12 December 2022

External DOI

PubMed ID

36508081

Department/Unit

  • Chemistry

Research Area

  • Cancer
  • Surgical Science and Practice
  • Chemistry and Pharmaceutical Sciences

Publisher

Springer Science and Business Media LLC

Version

  • Accepted Version (Postprint)

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    Royal College of Surgeons in Ireland

    Categories

    Keywords

    Disease OutbreaksLung InjuryDronabinolVapingElectronic Nicotine Delivery SystemsClinical SciencesPharmacology and Pharmaceutical SciencesEVALI epidemicTHC-O acetatepulmonary toxicityMass spectrometry (MS)activation energy (AE)keteneMedicinal and Biomolecular Chemistry not elsewhere classified

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