Royal College of Surgeons in Ireland
Vaping THC-O Acetate. Potential for Another EVALI.pdf (541.35 kB)

Vaping THC-O acetate: potential for another EVALI epidemic

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journal contribution
posted on 2023-04-13, 15:37 authored by Neal L Benowitz, Christopher Havel, Peyton Jacob, Donal O'SheaDonal O'Shea, Dan WuDan Wu, Jefferson Fowles

This brief report is to alert the public health community to the confirmed presence of Δ8-THC-O acetate in commercially available vaping products and the potential risk of pulmonary toxicity from vaping THC-O. The impetus for this study was the presence of the aryl acetate moiety in THC-O. Mass spectrometry (MS) evidence and activation energy (AE) calculations indicating that vaping of THC-O is likely to generate ketene, a suspected cause of lung injury, are provided. 



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Published Citation

Benowitz NL. et al. Vaping THC-O acetate: potential for another EVALI epidemic. J Med Toxicol. 2023;19(1):37-39.

Publication Date

12 December 2022

PubMed ID



  • Chemistry

Research Area

  • Cancer
  • Surgical Science and Practice
  • Chemistry and Pharmaceutical Sciences


Springer Science and Business Media LLC


  • Accepted Version (Postprint)