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Potential for release of pulmonary toxic ketene from vaping pyrolysis of vitamin E acetate [Version: 1]

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posted on 26.11.2021, 17:11 by Dan WuDan Wu, Donal O'SheaDonal O'Shea
The Centers for Disease Control and Prevention has recently reported an increasing number of clinically reported cases of lung injury following use of e-cigarette/vaping products. The cause(s) of this growing epidemic of vaping associated pulmonary injury remain unidentified, though vitamin E acetate has been recently identified as one possible causative agent (see Nature 574, 303 (2019). A combined analytical, theoretical and experimental study has shown that the vaping of vitamin E acetate has the potential to produce exceptionally toxic ketene gas, which may be a contributing factor to the upsurge in lung injuries associated with using some vaping products.


Synthesis and Solid State Pharmaceutical Centre



The original article is available at www.pnas.org and RCSI repository https://hdl.handle.net/10779/rcsi.13095374.v1 Pre-print is available on ChemRxiv https://doi.org/10.26434/chemrxiv.10058168.v1 Pre-print version 2 is available on ChemRxiv at https://doi.org/10.26434/chemrxiv.10058168.v2 and RCSI repository at https://hdl.handle.net/10779/rcsi.16997935.v1

Published Citation

Wu D, O'Shea D. Potential for release of pulmonary toxic ketene from vaping pyrolysis of vitamin E acetate. ChemRxiv 2019.

Publication Date

31 October 2019

PubMed ID



  • Chemistry

Research Area

  • Cancer
  • Surgical Science and Practice
  • Chemistry and Pharmaceutical Sciences


American Chemical Society (ACS)


  • Submitted Version (Preprint)