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Potential for release of pulmonary toxic ketene from vaping pyrolysis of vitamin E acetate. [Version:2]

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posted on 26.11.2021, 17:11 authored by Dan WuDan Wu, Donal O'SheaDonal O'Shea
The Centers for Disease Control and Prevention has recently reported an increasing number of clinically reported cases of lung injury following use of e-cigarette/vaping products. The cause(s) of this growing epidemic of vaping associated pulmonary injury remain unidentified, though vitamin E acetate has been recently identified as one possible causative agent (see Nature 574, 303 (2019). A combined analytical, theoretical and experimental study has shown that the vaping of vitamin E acetate has the potential to produce exceptionally toxic ketene gas, which may be a contributing factor to the upsurge in lung injuries associated with using some vaping products.

Funding

Synthesis and Solid State Pharmaceutical Centre

History

Comments

The original article is available at www.pnas.org and RCSI repository https://hdl.handle.net/10779/rcsi.13095374.v1 Pre-print version 1 is available on ChemRxiv https://doi.org/10.26434/chemrxiv.10058168.v1 and RCSI repository https://hdl.handle.net/10779/rcsi.16997956.v1 Pre-print version 2 is available on ChemRxiv at https://doi.org/10.26434/chemrxiv.10058168.v2

Published Citation

Wu D, O'Shea D. Potential for release of pulmonary toxic ketene from vaping pyrolysis of vitamin E acetate. ChemRxiv 2019.

Publication Date

6 December 2019

PubMed ID

32156732

Department/Unit

  • Chemistry

Research Area

  • Cancer
  • Surgical Science and Practice
  • Chemistry and Pharmaceutical Sciences

Publisher

American Chemical Society (ACS)

Version

  • Submitted Version (Preprint)