Medicinal and biomolecular chemistry

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E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1

E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1

journal contribution posted on 2024-10-22

FILES UNDER EMBARGO

Sodium-glucose cotransporter 2 inhibitors and renin-angiotensin-aldosterone system, possible cellular interactions and benefits

journal contribution posted on 2024-10-21

First approved CRISPR trial on sickle cell disease treatment

First approved CRISPR trial on sickle cell disease treatment

journal contribution posted on 2023-08-22

Understanding metastasis: current paradigms and therapeutic challenges in breast cancer progression

Understanding metastasis: current paradigms and therapeutic challenges in breast cancer progression

journal contribution posted on 2023-07-26

Molecular and physiological functions of PACAP in sweat secretion

Molecular and physiological functions of PACAP in sweat secretion

journal contribution posted on 2023-03-29

Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies.

Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies.

journal contribution posted on 2022-11-29

Sustained Expression of Steroid Receptor Coactivator SRC-2/TIF-2 is Associated with Better Prognosis in Malignant Pleural Mesothelioma.

Sustained Expression of Steroid Receptor Coactivator SRC-2/TIF-2 is Associated with Better Prognosis in Malignant Pleural Mesothelioma.

journal contribution posted on 2022-11-29

Dexamethasone reduces airway epithelial Cl- secretion by rapid non-genomic inhibition of KCNQ1, KCNN4 and KATP K+ channels

Dexamethasone reduces airway epithelial Cl- secretion by rapid non-genomic inhibition of KCNQ1, KCNN4 and KATP K+ channels

journal contribution posted on 2022-08-11

Ursodeoxycholic acid inhibits ENaC and Na/K pump activity to restore airway surface liquid height in cystic fibrosis bronchial epithelial cells

Ursodeoxycholic acid inhibits ENaC and Na/K pump activity to restore airway surface liquid height in cystic fibrosis bronchial epithelial cells

journal contribution posted on 2022-08-11

Guest editorial: 11th international meeting on rapid responses to steroid hormones RRSH2018

Guest editorial: 11th international meeting on rapid responses to steroid hormones RRSH2018

journal contribution posted on 2022-08-11

Protein kinase D2 regulates epithelial sodium channel activity and aldosterone non-genomic responses in renal cortical collecting duct cells

Protein kinase D2 regulates epithelial sodium channel activity and aldosterone non-genomic responses in renal cortical collecting duct cells

journal contribution posted on 2022-08-10

Effect of PACAP on sweat secretion by immortalized human sweat gland cells

Effect of PACAP on sweat secretion by immortalized human sweat gland cells

journal contribution posted on 2022-08-10

Aldosterone Regulation of Protein Kinase Signaling Pathways and Renal Na+ Transport by Non-genomic Mechanisms

Aldosterone Regulation of Protein Kinase Signaling Pathways and Renal Na+ Transport by Non-genomic Mechanisms

chapter posted on 2022-07-29

Estrogen inhibits chloride secretion caused by cholera and Escherichia coli enterotoxins in female rat distal colon.

Estrogen inhibits chloride secretion caused by cholera and Escherichia coli enterotoxins in female rat distal colon.

journal contribution posted on 2022-07-29

Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation.

Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation.

journal contribution posted on 2022-07-29

Cytosolic phospholipase A2-α expression in breast cancer is associated with EGFR expression and correlates with an adverse prognosis in luminal tumours.

Cytosolic phospholipase A2-α expression in breast cancer is associated with EGFR expression and correlates with an adverse prognosis in luminal tumours.

journal contribution posted on 2022-07-29

Cytosolic phospholipase A2 activation correlates with HER2 overexpression and mediates estrogen-dependent breast cancer cell growth.

Cytosolic phospholipase A2 activation correlates with HER2 overexpression and mediates estrogen-dependent breast cancer cell growth.

journal contribution posted on 2022-07-29

Novel aspects of oestrogen actions.

Novel aspects of oestrogen actions.

journal contribution posted on 2022-07-29

The effect of high [K(+)]o on spontaneous Ca(2+) waves in freshly isolated interstitial cells of Cajal from the rabbit urethra.

The effect of high [K(+)]o on spontaneous Ca(2+) waves in freshly isolated interstitial cells of Cajal from the rabbit urethra.

journal contribution posted on 2022-07-29

Lipoxin A4 stimulates calcium-activated chloride secretion and increases airway surface liquid height in normal and cystic fibrosis airway epithelia

Lipoxin A4 stimulates calcium-activated chloride secretion and increases airway surface liquid height in normal and cystic fibrosis airway epithelia

journal contribution posted on 2022-07-29

Estrogen receptor β exerts tumor repressive functions in human malignant pleural mesothelioma via EGFR inactivation and affects response to gefitinib.

Estrogen receptor β exerts tumor repressive functions in human malignant pleural mesothelioma via EGFR inactivation and affects response to gefitinib.

journal contribution posted on 2022-07-29

Dataset of KCNQ1, KCNN4, KATP channel expression and dexamethasone modulation of protein kinase signaling in airway epithelial cells

Dataset of KCNQ1, KCNN4, KATP channel expression and dexamethasone modulation of protein kinase signaling in airway epithelial cells

journal contribution posted on 2022-07-29

Berberine reduces cAMP-induced chloride secretion in T84 human colonic carcinoma cells through inhibition of basolateral KCNQ1 channels

Berberine reduces cAMP-induced chloride secretion in T84 human colonic carcinoma cells through inhibition of basolateral KCNQ1 channels

journal contribution posted on 2022-07-29

Position paper: Rapid responses to steroids: current status and future prospects.

Position paper: Rapid responses to steroids: current status and future prospects.

journal contribution posted on 2022-07-29

Aldosterone as a renal growth factor

Aldosterone as a renal growth factor

journal contribution posted on 2022-07-29

Malignant pleural mesothelioma incidence and survival in the Republic of Ireland 1994-2009.

Malignant pleural mesothelioma incidence and survival in the Republic of Ireland 1994-2009.

journal contribution posted on 2022-07-29

Mechanisms Underlying Rapid Aldosterone Effects in the Kidney

Mechanisms Underlying Rapid Aldosterone Effects in the Kidney

journal contribution posted on 2022-07-29

Rapid effects of 17beta-estradiol on TRPV5 epithelial Ca2+ channels in rat renal cells.

Rapid effects of 17beta-estradiol on TRPV5 epithelial Ca2+ channels in rat renal cells.

journal contribution posted on 2022-07-29

Novel female sex-dependent actions of oestrogen in the intestine.

Novel female sex-dependent actions of oestrogen in the intestine.

journal contribution posted on 2022-07-29

Non-genomic actions of aldosterone: From receptors and signals to membrane targets.

Non-genomic actions of aldosterone: From receptors and signals to membrane targets.

journal contribution posted on 2022-07-29

Pseudomonas aeruginosa PA5oct jumbo phage impacts planktonic and biofilm population and reduces its host virulence

Pseudomonas aeruginosa PA5oct jumbo phage impacts planktonic and biofilm population and reduces its host virulence

journal contribution posted on 2022-07-29

Protein Kinase D1 Modulates Aldosterone-Induced ENaC Activity in a Renal Cortical Collecting Duct Cell Line

Protein Kinase D1 Modulates Aldosterone-Induced ENaC Activity in a Renal Cortical Collecting Duct Cell Line

journal contribution posted on 2022-07-29

Sexual Dimorphism and Estrogen Regulation of KCNE3 Expression Modulates the Functional Properties of KCNQ1 K+ Channels

Sexual Dimorphism and Estrogen Regulation of KCNE3 Expression Modulates the Functional Properties of KCNQ1 K+ Channels

journal contribution posted on 2022-07-29

Effect of Estrogen on Pseudomonas Mucoidy and Exacerbations in Cystic Fibrosis

Effect of Estrogen on Pseudomonas Mucoidy and Exacerbations in Cystic Fibrosis

journal contribution posted on 2022-07-29

Bidirectional KCNQ1:β-catenin interaction drives colorectal cancer cell differentiation.

Bidirectional KCNQ1:β-catenin interaction drives colorectal cancer cell differentiation.

journal contribution posted on 2022-07-29

Physiological levels of lipoxin A4 inhibit ENaC and restore airway surface liquid height in cystic fibrosis bronchial epithelium.

Physiological levels of lipoxin A4 inhibit ENaC and restore airway surface liquid height in cystic fibrosis bronchial epithelium.

journal contribution posted on 2022-07-29

Genomic priming of the antisecretory response to estrogen in rat distal colon throughout the estrous cycle.

Genomic priming of the antisecretory response to estrogen in rat distal colon throughout the estrous cycle.

journal contribution posted on 2022-07-29

Estrogen increases ENaC activity via PKCδ signaling in renal cortical collecting duct cells.

Estrogen increases ENaC activity via PKCδ signaling in renal cortical collecting duct cells.

journal contribution posted on 2022-07-29

collection:
Aldosterone-Mineralocorticoid Receptor: Cell Biology to Translational Medicine

posted on 2022-07-04

Ursodeoxycholic acid attenuates colonic epithelial secretory function.

Ursodeoxycholic acid attenuates colonic epithelial secretory function.

journal contribution posted on 2022-04-07